Role of SR-BI in breast cancer

Cancer Science & Therapy

ISSN: 1948-5956

Open Access

Role of SR-BI in breast cancer

12th World Cancer Conference

September 26-28, 2016 London, UK

Jorge L Gutierrez-Pajares

University of Tours, France

Posters & Accepted Abstracts: J Cancer Sci Ther

Abstract :

Disorders in lipid metabolism have now been implicated in the development of many diseases including cancer. The contribution of lipid metabolism to cancer progression is still poorly understood in part due to the complexities of lipid metabolism regulation. While the role of cholesterol and other lipids has been evident for many years in cardiovascular diseases, their role in cancer development and progression is to be elucidated. Studies have demonstrated the significant role of cholesterol and lipoprotein metabolism in the development of cancer. The SCARB1 gene encodes an 82 kDa glycoprotein named the scavenger receptor class B type I (SR-BI). SR-BI plays a crucial role in the regulation of cholesterol exchange between cells and high-density lipoproteins. Since lipid metabolism is a relevant target for cancer treatment, recent studies have focused on examining the role of SR-BI in this pathology. While signaling pathways have initially been explored in non-tumoral cells, studies with breast cancer cells have now demonstrated SR-BI├ó┬?┬?s function in tumor development. In this study, the role of SRBI in malignant progression as well as useful information for the development of new therapeutic strategies will be discussed.

Biography :


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