Alok D Singh, Vandana Panda and S Sudhamani
Principal K M Kundnani College of Pharmacy, India
Dr. D Y Patil Medical College, India
Posters & Accepted Abstracts: J Metabolic Synd
The present study evaluates the protective effects of Garcinia indica fruit rind extract (GIE) in abnormalities associated with the metabolic syndrome (MetS) in rats. Rats administered with high fat diet (HFD) and fructose (20% w/v) in drinking water for 45 days to induce abnormalities associated with the MetS. Rats received GIE (400 and 800 mg/kg, po), the standard drug gemfibrozil (60 mg/kg, po), aerobic exercise (AE), and combination of GIE 800 mg/kg and AE (GIEAE) daily for 45 days. All treatment animals showed a significant reduction in food intake, body weight, body mass index (BMI), and abdominal circumference (AC). A significant decrease in blood glucose and insulin levels decreased insulin resistance, and improved glucose tolerance was observed in the treatment animals when compared with HFD and fructose fed animals. All treatment significantly altered lipid profile and attenuated the levels of uric acid, C-reactive protein, TNF-α, and marker enzyme (AST, LDH and CK-MB) in serum and malondialdehyde in heart and restored the depleted levels of glutathione and antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase) and significant elevation was observed in adiponectin levels. The best mitigation was shown by GIEAE treatment indicating that regular exercise along with adequate consumption of antioxidant and polyphenol rich kokum in diet can help control MetS.
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Journal of Metabolic Syndrome received 506 citations as per Google Scholar report