Ememe M U, Abdullahi U S, Sackey A K B and Ayo J O
Ahmadu Bello University, Nigeria
Posters & Accepted Abstracts: J Vet Sci Technol
This study was aimed to evaluate themodulatory effects of Equithrive joint supplement on oxidativestress and inflammatory biomarkers in aged lame horses. A total of 16 horses of both sexes, weighing between 350 and 450 kg were used. Eight of the horses were administered with equithrive joint for four weeks and eight others served as untreated (controls), and were given only Saccharomyces cerevisiae yeast strain used as carrier in the supplement. Blood samples were collected from each horse before supplementation (week 0) and at first, second, third and fourth week of the experiment. Activities of oxidative biomarkers (catalase, glutathione peroxidase, malondialdehyde and superoxide dismutase) and concentration of the inflammatory biomarker, tumor necrosis factor-alpha were determined by standard methods. Equithrive joint administration increased (P<0.05) the activities of catalase and superoxide dismutase, while glutathione peroxidase activity, malondialdehyde and tumour necrosis factor alpha concentrations reduced (P<0.05) in the treated horses, compared with the controls (untreated). The result indicated that Equithrive joint is a potent antioxidant and anti-inflammatory agent, which may be of value in reducing inflammatory mediators; thereby improving locomotion in aged lame horses.
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