Central Forensic Science Laboratory, India
Posters-Accepted Abstracts: Pharmaceut Reg Affairs
In various drug testing laboratories, the need for analyzing drugs of abuse and their metabolits at ultra-trace levels in complex biological sample has made the sample preparation most important and critical step. Additionally, the demand for sensitive, selective, economcial and robust analytical methods, lead the reseachers to focus on sample preparation methods which can overcome the disadvantages of traditional extraction methods such as liquid-liquid extraction (LLE). Modern microextraction techniques such as liquid phase microextraction (LPME) and solid-phase microextraction SPME) are the two technique which have gained significant attraction from the researcher all over the globe in drug analysis. The consumption of zero, or microlitres of extraction solvent, high extraction efficiencies, high enrichment factors, ease of operation, environmentally frinedliness and rapidity are the major advantages of modern microextraction techniques. Dispersive liquid-liquid microextraction (DLLME), LPME and SPME have been widely used for the extraction and pre-concentration of drugs of abuse such as amphetamines, benzodiazepines, cocaine, LSD etc. The present article is a discussion on the applications and pros and cons of microextraction techniques for the analysis of drugs of abuse in biological matrices.
Pharmaceutical Regulatory Affairs: Open Access received 471 citations as per Google Scholar report