MicroRNAs in lung cancer development and drug resistance

International Conference and Exhibition on Lung Disorders & Therapeutics

July 13-15, 2015 Baltimore, Maryland, USA

Bing-Hua Jiang

Posters-Accepted Abstracts: J Pulm Respir Med

Abstract :

Our recent study demonstrates that a number of microRNAs (miRNAs) are downregulated in human lung cancer and those levels of miRNA suppression correlate with advanced cancer stages and drug resistance. The miRNA suppression is involved in inducing tumor growth and angiogenesis through the induction of their direct target genes. To understand the suppression mechanism, we found that some miRNAs are inhibited by the DNA methylation while some miRNAs are inhibited by higher levels of reactive oxygen species (ROS) production in cancer cells. MiRNA suppression is important for autophagy response and drug resistance.