Basil O. Saleh, Wasan F. Ibraheem and Nada S. Amin
Accepted Abstracts: J Cancer Sci Ther
Background:The Polycystic ovary syndrome (PCOS) is established in the presence of two of the three following criteria: clinical and / or biochemical hyperandrogenism, chronic oligo-anovulation and polycystic ovarian morphology in ultrasound. Long- term metformin treatment may increase ovulation, improve menstrual cyclicity, and decrease androgen levels in these patients. Aim: The aim of this study was to investigate the effectiveness of short and long term metformin treatment in Iraqi PCOS women and the role of anti-mullerian hormone (AMH) levels in assessment of this treatment. Subjects and Methods: This study was carried out at biochemistry department, college of medicine, University of Baghdad, Iraq. It included twenty PCOS women aged (18-38 year) studied on cycle day (cd) from 2-4 (group I). These women were followed up after they were used metformin hydrochloride tablet 500 mg three times daily for 3 months (and considered as group II). Moreover, 18 PCOS women aged (22-36 year) who were already on metformin hydrochloride treatment 500 mg tablet three times daily for 6 months to 3 years and was studied on cd 2-4 ( and considered as group III). Serum investigations included measurements of AMH, FSH, LH, Free Testosterone, E2, prolactin and 17- alpha hydroxyprogesterone. Furthermore, ultrasonic study included ovarian volume and number of ovarian follicles was also studied. Results: The mean (?SEM) value of serum AMH levels was significantly decreased in group II with short term metformin treatment when compared with that of Group I PCOS women before treatment (P<0.01). In addition, the mean of serum AMH levels of group II was insignificantly reduced in comparison with that of Group III long term treatment (P>0.05). However, there was no significant difference in serum AMH mean value between Group I and Group III. Conclusions: This study revealed the effectiveness of three months short term metformin treatment in Iraqi PCOS women and the efficacy of serum AMH measurement in evaluation of this treatment. Long term metformin treatment of more than 3 months has no advantage over that of short treatment in correction of PCOS condition. Keywords: PCOS, metformin hydrochloride, AMH.