Manganese enhancement magnetic resonance imaging (MEMRI) as imaging biomarker of calcium channels

Molecular Biomarkers & Diagnosis

ISSN: 2155-9929

Open Access

Manganese enhancement magnetic resonance imaging (MEMRI) as imaging biomarker of calcium channels

5th International Conference on Biomarkers & Clinical Research

April 15-17, 2014 St. Hilda’s College - University of Oxford, UK

Francesca Rosa, Luca Basso, Michele Cilli, Laura Emionite, Francesca Valdora, Daniele Pace, Carlo Emanuele Neumaier and Gabriella Baio

Posters: J Mol Biomark Diagn

Abstract :

M anganese-enhanced Magnetic Resonance Imaging (MEMRI) evolved in the late nineties and relies upon the following three main properties of Mn 2+ : 1) it is a paramagnetic ion and an excellent T1 relaxivity; 2) it is a calcium (Ca 2+ ) analog that can enter excitable cells (voltage-gated calcium receptor and calcium sensing receptor) and, 3) once in the cells Mn 2+ can be transported along axons by microtubule-dependent axonal transport. The above mentioned properties of Mn 2+ make it a particularly attractive contrast agent for MRI in order to study physiology and physiopathology of: 1. Brain 2. Heart 3. Salivary glands 4. Cancer Different animal models were prepared to investigate the application of Manganese as contrast agent by using a clinical 3T MR scanner and a prototype birdcage coil. The results of our study highlighted the potential utility of MEMRI as ?functional tool? in order to study the physiological activity of the brain, heart and salivary glands and the different expression of calcium sensing receptor in breast and prostate cancer. In conclusion, our results open the exploration of MEMRI as a new possible ?imaging biomarker? of calcium metabolism in human disease.

Biography :

Francesca Rosa is a medical undergraduate student at the School of Medicine, at the University of Genoa, Italy. Her field of research is on the application of new contrast agent for tumor targeting. Actually, she is involved in a research project about autoimmune disease and the application of Manganese as ?imaging biomarker?. She was recently, awarded with the ?Magna Cum Laude? at the European Congress of Radiologist (ECR) in Vienna (6-10 March 2014).

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