Intercellular crosstalk in malignant melanoma

14^th Asia Pacific Oncologists Annual Meeting

November 20-22, 2017 Melbourne, Australia

Pavol Szabo, Lukas Lacina, Barbora Dvorankova and Karel Smetana

Charles University, Czech Republic
East-Slovak Institute of Cardiovascular Diseases Inc., Slovakia

Scientific Tracks Abstracts: J Cancer Sci Ther

Abstract :

The incidence of melanoma is increasing globally and curability of advanced disease is still limited. Similarly, to other types of tumors, the microenvironment is an important factor participating in the control of melanoma biological behavior. The principal cell populations of melanoma microenvironment include cancer-associated fibroblasts (CAFs), keratinocytes, tumor-infiltrating leukocytes, endothelia of newly formed vessels and also, the composition of extracellular matrix (ECM) must be taken into account in this context. The CAFs produce various types of extracellular matrix proteins and a wide panel of cytokines/chemokines and growth factors such as IL-6, IL-8, and CXCL-1. CAFs isolated from melanoma stimulate aggressive behavior of tumor cells. Effect of CAF on other types of cells present in melanoma was also well documented. From this point of view, CAFs as the key factor of melanoma microenvironment represent a potential target for a new type of anti-tumor therapy.

Biography :

Pavol Szabo completed PhD and has lot of experience in studying cancer-stroma interactions. He has focused his research in most abundant cell compartment of cancer microenvironment cancer associated fibroblasts (CAFs) and use tissues, in vitro, in vivo samples to understand role of CAFs to form reactive cancer microenvironment.