Ruchi Gaur and Lallan Mishra
Accepted Abstracts: J Cancer Sci Ther
For rather a long period of time, it has been widely accepted that cancer was caused by gene mutations which is termed somatic mutation theory (SMT). But now the SMT theory has met with increasing doubts, disbelieves, and been facing challenges from other alternative theories. From a pathological perspective, and with the evidences from molecular pathology, hisopathology, and epidemiology, the study shows that the 80 year old paradigm of carcinogenesis process from atypia to in situ carcinoma to invasive cancer is wrong. Since 90% of the human cancers are epithelially derived "carcinomas", the turnover of this paradigm naturally negates the SMT theory for SMT sits on this model. The invasive cancer grows out in the stroma de novo from misplaced stem cells rather than deriving from the transformed in situ carcinoma cells. Also, the talk will show evidences that cancer cells are not so- believed "apoptosis-resistant", but rather "short-lived sick cells". In fact, it is the increased cell death which makes the cancer cells proliferate ceaselessly to compensate for the cell loss, and move to new locations for better chance of survival. This novel cancer theory is designed as SCMT, stem cell misplacement theory. This theory is backed by huge amount of solid evidences and will bring revolutionary conceptual changes to our understanding and treatment of cancer, e.g., in situ carcinomas are not genuine cancer biologically, thus should not be treated the same as cancer.
Rui-An Wang is a Professor of Pathology. After graduation from medical school, he first worked as a histology and embryology teacher and both his MS and Ph.D. degree thesis were on the study of gut endocrinology. In his postdoctoral training, he did reproductive biology, and then shifted to the mammary gland development and carcinogenesis by using molecular biology and gene modified animal techniques. His large gamut of research gave him a pair of eyes by which he sees a lot of scientific issues differently. The SCMT theory he formulated views cancer in a rather different way, and possibly will bring some change to the field.