Heritability and familiarity of type 2 diabetes in Yazd population, Iran

International Conference on Metabolic Syndromes

October 17-18, 2016 Rome, Italy

Ensieh Shahvazian, Mohammad Bagher Mahmoudi, Saba Gharibi and Ehsan Farashahi Yazd

Shahid Sadoughi University of Medical Sciences, Iran
ROJETechnologies, Iran

Posters & Accepted Abstracts: J Metabolic Synd

Abstract :

Type 2 diabetes (T2D) is the growing health problem in Yazd population, having a prevalence of 16.3% among adolescent. The level of consanguineous marriage is high (46%), hence a high level of homozygosity is predictable. Besides, this population has special predisposing life style of low relocation rates, a relatively high standard of living, large family sizes. To direct association and linkage studies in Yazd, we decided to calculate the heritability of type 2 diabetes in a population based family study. 2065 individuals were participated in the Yazd Diabetes Study (YDS). The study was conducted among diabetic probands between 35-80 years, whose disease were confirmed in Yazd Diabetes Research Center, and their expanded families. Heritability was calculated for type 2 diabetes in SOLAR software package and was adjusted for common covariates (age, sex, age �� sex, age2 and BMI). The strongest heritability for type 2 diabetes (h2=0.56�±0.28, P value=0.016) was seen in age group 40-60 years. However, in age group 20-60 years, heritability reduced to 0.22�±0.2. The heritability for 40-75 years was 0.28�±0.11. �»R=2.4 and �»R (nuclear family)=3.42 and �»S=3.14 was seen in age group of 35 to 80 years. As a conclusion, for detecting high influenced genetic risk factor with ORâ�¥2, it is recommended to conduct studies on individuals between 40 to 60 years. To cover all genetic risk factor either with less OR, it is better to limit the sample study on individuals with onset 40 to 75 years.

Biography :

Email: nc.shahvazian@gmail.com