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Genetic polymorphism of apolipoprotein E in hemorrhagic stroke: Case-control study
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Molecular and Genetic Medicine

ISSN: 1747-0862

Open Access

Genetic polymorphism of apolipoprotein E in hemorrhagic stroke: Case-control study


Joint Meeting on 4th World Congress on Human Genetics & Genetic Diseases and 3rd International Conference on Molecular Medicine & Diagnostics

April 19-20, 2018 Dubai, UAE

Sabrina Boumendjel, Djamel Khodja, Abdelmajid Hamri, Cherifa Benlatreche and Noureddine Abadi

Constantine 1 University, Algeria

Posters & Accepted Abstracts: J Mol Genet Med

Abstract :

Aim: It is a case-control study realized at the Hospital of Constantine. It discusses the relationship between polymorphism of apolipoprotein E and hemorrhagic stroke. Method: The determination of the polymorphism of apolipoprotein E was carried out by PCR-digestion (polymerase chain reaction) using the enzyme of restriction HhaI. The study population consisted of 81 Algerian patients with hemorrhagic stroke and 509 control subjects. Results: Three isoforms of apolipoprotein E have been identified. The allelic distribution of apoE in the general population showed a predominance of the allele ���µ3 (84.3%) followed distantly by allele ���µ4 (10.7%) and ���µ2 (5%) respectively. In hemorrhagic stroke patients, allele frequencies of ���µ4 and ���µ2 are respectively 10.5% and 3.3%. These frequencies are not statistically different as reported in the control group. The assessment of the odds ratio of patient subjects with allele ���µ4, ���µ2, ���µ3/���µ4 and ���µ2/���µ3 compared to control subjects with genotype ���µ3/���µ3 did not show any statistical association between the polymorphism of the apoE and the set of hemorrhagic stroke. Conclusion: The distribution of apolipoprotein E allele frequencies in the population of Constantine is similar to that of Southern Europe. The ���µ2, ���µ4 alleles do not appear to be implied in the occurrence of this affection; nevertheless, large additional studies are necessary to confirm these results. sabboumendjel@yahoo.fr

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