Accepted Abstracts: J Cancer Sci Ther
Purpose of the report:To review the histopathology, and presentation of metastatic gastrointestinal neuroendocrine carcinoma to a submandibular lymph node. Background: Gastrointestinal neuroendocrine tumors (GNET) are rare slow growing tumors that have the capacity to develop carcinoid syndrome. These carcinoid tumors most often arise from the gastrointestinal tract or lungs and commonly metastasize to regional lymph nodes, liver, lungs, and bone. Rarely do these tumors metastasize to the lymph nodes of the neck. We present a case of a 54 year old woman with metastatic GNET to the neck. Design of study and analysis: Review of histopathology slides of a fine needle aspirate (FNA) performed on a submandibular neck mass, and comparison with previous histopathology slides obtained from a colectomy and hepatectomy performed 16 months prior. Results/Case Presentation: A 54 year old woman with a history of a stage IV T3N1M1 large cell neuroendocrine carcinoma metastatic to the liver status post right hemicolectomy (16 months prior) and partial hepatectomy (6 months prior) presents to the head and neck surgery clinic with a 1 month history of a firm, enlarging left submandibular mass. FNA was performed and was revealed cells identical to those present in a metastatic liver nodule, and a colectomy specimen. Pathologic examination revealed a poorly differentiated carcinoma with numerous mitotic figures, amphophilic cytoplasm, round nuclei with salt and pepper chromatin, in a trabecular growth pattern. Conclusion: Although GNET rarely metastasize to the neck, metastatic disease should be part of the differential for patients with a prior history of GNET.