FORMULATION DEVELOPMENT AND INVITRO EVOLUTION OF SUSTAINED RELEASEVERAPAMIL HCL MATRIX RELEASE TABLETS BY USING DIFFERENT NATURAL POLYMERS

27^th International Congress on Pharmaceutical Biotechnology Research

June 23-24, 2025 Webinar

Santhosh L, Ekshitha G, Rajkiran K

Department of Pharmaceutics, Sri Sivani College of Pharmacy, India

Scientific Tracks Abstracts: Pharm Regul Aff

Abstract :

Various natural polymers will be used in the formulation and evaluation of the sustained release (SR) matrix tablets ofVerapamil Hydrochloride (HCl) in this study to provide controlled drug release over a longer period of time. VerapamilHCl, a calcium channel blocker with a short half-life, requires frequent dosing, which can be overcome by developingsustained release formulations. Due to their biocompatibility, non-toxicity, and capacity to regulate drug release, naturalpolymers like Okra gum, Xanthan gum, and Guar gum were chosen as matrix-forming agents. The sustained releasematrix tablets were prepared using the wet granulation method and subjected to various pre-compression and post-compression evaluation parameters, including flow properties, hardness, friability, weight variation, drug content, andswelling index. In-vitro drug release studies were conducted using USP dissolution apparatus in 0.1N HCl and phosphatebuffer pH 7.4 to simulate gastrointestinal conditions.The results revealed that formulations.release. Among all formulations, the combination of natural polymers provided a synergistic effect, significantlyretarding drug release compared to single polymer systems.The study came to the conclusion that natural polymersare promising excipients for the development of Verapamil HCl sustained release matrix tablets because they provideadvantages such as decreased dosing frequency, increased patient compliance, and pharmacokinetic profiles that arepredictable. Keywords: . Verapamil Hydrochloride, Sustained Release, Natural Polymers, Okra Gum, Xanthan Gum, Guar Gum, MatrixTablets, Controlled Drug Delivery, In-vitro Evaluation, Release Kinetics.

Biography :

L.Santhoshi has her own experience in valuation and passion for ML and data. The research team built this model after many years ofexperience in research, evaluation, work in both hospitals and scientific laboratories. This approach meets all the requirements forprecise, specific, sensitive diagnostics.