E-SITE-Experimental facilities of small intestinal tissue engineering

Journal of Tissue Science and Engineering

ISSN: 2157-7552

Open Access

E-SITE-Experimental facilities of small intestinal tissue engineering

2nd International Conference & Exhibition on Tissue preservation and Bio-banking

September 12-13, 2016 Philadelphia, USA

Andrea Ferencz

Semmelweis University, Hungary

Posters & Accepted Abstracts: J Tissue Sci Eng

Abstract :

The small bowel has long been considered as a â??forbiddenâ? organ to transplant and in fact, is the last of the splanchnic viscera to have acceded to the clinical area. Early clinical experience was almost universally unsuccessful. Although, in 2015 the 5-year graft survival of the small bowel transplantation is closed to 65-70% in some centers, the widespread application of this procedure is still limited by the relatively high rate of complications. The majority of potential candidates for intestinal transplantation are those adult and child patients who have short-bowel syndrome after extensive intestinal resection or malfunction. Therefore, there is a significant need for tissue engineering and regenerative medicine approaches aimed at generation of implantable or in situ forming tissues and organs. In tissue engineering approach, cells are seeded in a biodegradable matrix or scaffold. Nanomaterials and the stem cell technology have a key role to play in tissue replacement. For these purposes, 3D printed grafts (POMaC Polymer: Useable for cardiomyocytes, fibroblasts, endothelial cells â?? to build layered structures) or Laser printing of Three-dimensional Multicellular Arrays for studies of cell-cell and cell-environment interactions are usable for these purposes. For the evaulation of biological effects of 3D graft, the scaffold with and without adipose tissue stem cells (ASCs) should be used for implantation of small segment of the bowel in experimental animal models.

Biography :


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