Fabienne Bon, Tracy Paradis, Alicia Loiselet, Amandine Ducreux, Christophe D’Enfert and Frederic Dalle
UMR A PAM-University Bourgogne-Franche-Comte, France
Institut Pasteur, France
Centre Hospitalier Universitaire, France
Posters & Accepted Abstracts: J Med Microb Diagn
Formerly a commensal resident of the gut microbiota in healthy humans, Candida albicans is an opportunistic
pathogen causing infections ranging from superficial to the more life-threatening disseminated infections,
especially in the ever-growing population of vulnerable patients in hospital settings. Because overwhelming evidences
suggest that the gastrointestinal tract is the main source of disseminated C. albicans infections, deciphering the
cellular and molecular mechanisms of the interaction of C. albicans with enterocytes is necessary to better understand
the switch from commensalism to pathogenicity of this fungus and to improve the management of disseminated
candidiasis. Different routes of the gut barrier translocation by C. albicans have been reported, including transcytosis
through epithelial cells and the paracellular route where the fungus can cross the gut barrier without damaging the
tissue barrier. The intestinal epithelium indeed consists in a monolayer of enterocytes where adjacent cells are jointed
each other by cell junctions. Among those, tight junctions ensure integrity and impermeability of the intestinal
barrier, limiting invasion of the gut barrier by Candida albicans. We propose to investigate the modulation of tight
junction integrity during Candida albicans interaction with enterocytes and specify the mechanisms allowing the
fungus to cross the gut barrier through the paracellular route.
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Bon Fabienne is a Research Teacher at the University of Burgundy. Her work aims to improve knowledge on the pathophysiology of Candida albicans and more specifically on the interaction of this agent with enterocyte cells. The objective is to understand the cellular and molecular mechanisms involved in the passage of Candida albicans from commensalism to the pathogenic state.
E-mail: [email protected]
Medical Microbiology & Diagnosis received 1059 citations as per Google Scholar report