Efficacy of Curcuma longa on histology of ovary under endosulfan induced toxicity

2^nd International Conference and Exhibition on Traditional & Alternative Medicine

August 25-26, 2014 DoubleTree by Hilton Beijing, China

Arti Kumari

Posters: Altern Integ Med

Abstract :

I ndia has a rich history of plants being used for medicinal purposes. Curcuma longa L. is extensively used as a spice, food preservative and colouring material in India, China and South East Asia. Curcuma longa (Fresh rhizome and its dried powder) has been used in traditional systems of medicine, like Ayurveda, Unani and Siddha as a household remedy for various diseases. In the last few decades, extensive work has been done to establish the biological activities and pharmacological actions of Curcuma longa and its extracts. Curcuma longa has been shown to have a wide spectrum of biological actions like anti-inflammatory, antioxidant, anti-carcinogenic, antimutagenic, anticoagulant, antifertility, anti-diabetic, antibacterial, antifungal, antiprotozoal, antiviral, antivenom and antiulcer activities. Studies were carried out to evaluate the efficacy of Curcuma longa on an organ affected by pesticide induced toxicity in female Swiss albino mice. Endosulfan, a chlorinated cyclodiene insecticide, was administered orally at 3mg per kg body weight per day one time to normal mice for 12 weeks. Further they were administered aqueous rhizome extracts of Curcuma longa for 12 weeks. Mice were sacrificed on the day next to the last day of treatment. Their ovaries were excised and fixed. A few other parameters were also studied. Observations showed deformities in ovarian tissue of Endosulfan exposed mice. However, histological study of Curcuma longa treated mice showed marked recovery. It was effective in reduction of degenerative effects, altered LPO level and restoration of weight. Hence Curcuma longa has the potential to mitigate the pesticide induced toxicity.

Biography :

Arti Kumari has pursuing her PhD from Magadh University, Bodh-Gaya, Bihar, India. She is SRF in a project of Indian Council of Medical Research, New Delhi, India. She has published papers in reputed journals.