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Effects of thalamic deep brain stimulation in the pilocarpine model of temporal epilepsy for rodents
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Neurological Disorders

ISSN: 2329-6895

Open Access

Effects of thalamic deep brain stimulation in the pilocarpine model of temporal epilepsy for rodents


3rd International Conference on Epilepsy and Treatment

August 31 - September 01, 2017 Brussels, Belgium

Luciene Covolan

Universidade Federal de Sao Paulo, Brazil

Keynote: J Neurol Disord

Abstract :

Deep brain stimulation (DBS) has been proposed as an alternative treatment for patients with epilepsy who are refractory to conventional treatment. There is a consensus that high frequency stimulation of the anterior nucleus of thalamus (ANT) is capable to reduce seizure frequency. Our group has focused on studies of ANT DBS in pilocarpine model of temporal lobe epilepsy. Here, I�ll present the data relative to the effects of ANT DBS in the acute and chronic phases of this rodent model, focusing in some interesting aspects of hippocampal excitabilitiy, plasticity, neuroprotection and spatial memory.

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Citations: 1253

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