Effects of Spirulina platensis on the immune status, anti-inflammatory and oxidative markers in HIV patients on antiretroviral therapy in Cameroon

11^th International Conference on Medicinal Chemistry & Pharmaceutical Technology

April 01-02, 2019 | Prague, Czech Republic

Ama Moor Vicky Jocelyne,Pieme Constant Anatole, Biapa Nya Cabral Prosper, Ikomey Georges, Okomo Cecile,Nkeck Jan Rene and Ngogang Yonkeu Jeanne

University of Yaounde, Cameroon
University of Dschang, Cameroon

Scientific Tracks Abstracts: Med Chem

Abstract :

Background & Aim: Spirulina platensis is traditionally used as a food supplement with a potential strengthening of the immune system, inhibition of the replication of some viruses, and lipid-lowering. The aim of this study was to determine its anti-inflammatory, immunologic, and anti-oxidative effects in HIV patients on antiretroviral therapy (ART).

Methods: We performed a clinical trial on 62 HIV patients on ART (Tenofovir- Lamivudine-Efavirenz) divided into two groups. Group I supplemented with 10 grams of Spirulina platensis daily, and group II receiving dietary advices. Participants were followed for six months, from December 2015 to June 2016. Each group were sampled for CD4-count, viral load, serum levels of interleukins 6 and 8, TNFα and oxidative markers (malondialdehyde, FRAP, catalase, total peroxides, superoxide dismutase, glutathione peroxidase, reduced glutathione) at the beginning (T0) and the end of the trail (T1). Ethical clearance was obtained from the national committee on ethics of human health research in Cameroon (Ref 2016/01/699/CE/CNERSH/ SP). Statistical analysis was performed using the software SPSS 18.0. The threshold of significance was set at 0.05.

Results: Mean ages of participants were 35±8 and 37±7 respectively for group I and II. We observed a significant decrease in viral load in patients receiving Spirulina comparing at T0 and T1 (p=0.04), and as compared to participants in group II (p=0.01). CD4-court was unchanged. There was a significant reduction of IL8 and TNFα levels in both groups but not statistically related to the supplementation. The levels of pro-oxidative markers have significantly decreased and antioxidant levels significantly increased in group I, compared to group II.

Conclusion: Daily supplementation of Spirulina platensis could improve the immune status of HIV patients on ART, and decrease inflammatory and pro-oxidant levels.

Biography :

Ama Moor Vicky Jocelyne is a Medical Doctor since 17 years; specialized in Clinical Pathology since 10 years and received her PhD degree in the year 2018 from University of Yaounde in Cameroon. She is working on Dyslipidemia Occurrence in Cameroon, and has interest on Spirulina platensis a microalgae with a lot property. She is Associate Professor in the Department of Biochemistry, Faculty of Medicine and Biomedical Science at the University of Yaounde. She has published more than 45 papers in reputed journals.

E-mail: movicky@yahoo.fr