GET THE APP

Effectiveness of birth dose of hepatitis B vaccine to the conventional 3-dose of pentavalent (DTP+HEPB+ HIB) vaccine among infants in rural Bangladesh
..

Cancer Science & Therapy

ISSN: 1948-5956

Open Access

Effectiveness of birth dose of hepatitis B vaccine to the conventional 3-dose of pentavalent (DTP+HEPB+ HIB) vaccine among infants in rural Bangladesh


4th World Congress on Cancer Science & Therapy

October 20-22, 2014 DoubleTree by Hilton Hotel Chicago-North Shore Conference Center, USA

Md. Shamsuzzaman, Pratap Singhasivanon, Jaranit Kawkaonwal, Saranath Lawpoolsri, Pisit Tankajvinich, Robert V Gibbons, Mahmudur Rahman, S M Alamgir and Mamun Al Mahtab

Accepted Abstracts: J Cancer Sci Ther

Abstract :

Background: Many countries have introduced the birth dose of hepatitis-B vaccine in their national immunization program aiming to reduce hepatitis B disease burden by preventing the perinatal transmission of hepatitis-B viral infection. Bangladesh has not yet introduced birth dose of hepatitis B vaccine in national immunization program and it needs evidence based information on the superiority in effectiveness of birth dose of hepatitis B vaccine among the infants in Bangladeshi context before taking decision on introduction of birth dose of hepatitis vaccine in national immunization program. No such study has been conducted in Bangladesh so far before this study. Objective: To compare the effectiveness of hepatitis B vaccine with and without a birth dose among the Bangladeshi infants. Materials and Methods: A multicenter open label randomized controlled trial where 486 newborn delivered by 480 mothers were randomly assigned to either receive conventional 3 doses of hepatitis B containing pentavalent (DTP+Hep-B+Hib) vaccine (control group) at 6,10 and 14 weeks or receive monovalent hepatitis B vaccine at birth in addition to the 3 doses of pentavalent vaccine(intervention group). Blood samples were drawn one month after the 3rd dose of pentavalent vaccine to assess seroprotection against hepatitis B and the seroprevalance of HBsAg among the vaccinated infants. Results: Out of 486 infants, 463 completed the study, where 234 and 229 infants were randomly assigned to the intervention group and the control group respectively. Overall, 99.4 % of infants achieved protective (anti-HBs: ≥10 mIU/ml) level of antibody. The seroprotection rate was 99.2 % and 99.6 % among infants in the intervention group and the control group respectively. In general, the geometric mean titer (GMT) was 39.4 mIU/ml. This GMT was 38.7 mIU/ml in the intervention group and 40.9 mIU/ml in the control group. Gestational age and mother?s education level were associated with antibody level among the infants (p=0.03). No infant was found to be positive with HBsAg. Conclusions: Both schedules (with and without birth dose) of hepatitis B vaccine were well effective in terms of immune response, which indicates that the existing hepatitis B vaccination schedule in national immunization program in Bangladesh is well effective and need not to give birth dose of monovalent hepatitis B vaccine in addition to the conventional 3 doses of hepatitis B containing pentavalent vaccine.

Google Scholar citation report
Citations: 3968

Cancer Science & Therapy received 3968 citations as per Google Scholar report

Cancer Science & Therapy peer review process verified at publons

Indexed In

 
arrow_upward arrow_upward