Effect of GABA on female reproductive hormones and ovarian tissues of albino rats

Global Veterinary Summit

August 31- September 02, 2015 Orlando-FL, USA

Fatma Ali1, Hassan Ahmed1, Mohie Haridy1, Ahmed Ezzat1, Abdelaziz Tammam1, Ahmed Ibrahim1 and Eid Abdelhamid2

1South Valley University, Egypt 2Beni-Seuf University, Egypt

Posters-Accepted Abstracts: J Veterinar Sci Technolo

Abstract :

Neurotransmitters are playing an important role in neuronal, neuromuscular and neuro-endocrine interactions through postsynaptic effect. The main site of neurotransmitters action is brain so any disturbance of their synthesis leading to neurological, mental and psychological disorders. GABA is the main inhibitory neurotransmitter in the brain. In the present study, the harmful effect of GABA on Female Reproductive Hormones and Ovarian Tissues were investigated. Fifteen Adult female albino rats were divided in to three groups; group one (control group n=20), group two (GABA treated group n=30rats were I.P injected GABA 1 mg/rat for 16days) and group three (recovery group without treating by GABA for 12 days n=15 rats), sera were collected every two days to determine LH, FSH, estrogen and progesterone hormones levels in follicular and luteal phases. Also ovaries were collected for histopathological examination. GABA showed significant (P<0.05) increase in the levels of LH, estrogen and progesterone while a significant (P<0.05) decrease in the level of FSH was observed. The ovarian histopathology showed by GABA revealed vasodilatation, hemorrhage, hyperplasia of interstitial glands and degeneration of oocyte. Interestingly, all these changes have not been completely recovered 12 days after last injection, although partial recovery of hormones and ovarian tissue were observed. It concluded that GABA has immediate harmful effects on female reproduction through hypophyseal-gonadal axis.

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