Effect of antiepileptic drugs on antioxidants in persons with epilepsy in Nigeria

Neurological Disorders

ISSN: 2329-6895

Open Access

Effect of antiepileptic drugs on antioxidants in persons with epilepsy in Nigeria

2nd International Conference on Epilepsy & Treatment

October 20-21, 2016 Rome, Italy

Emmanuel Iwuozo

Federal Medical Centre, Nigeria

Posters & Accepted Abstracts: J Neurol Disord

Abstract :

Epilepsy is one of the most common serious brain disorders prevalent in Africa including Nigeria. This study investigated the effect of antiepileptic drug (AED) therapy on serum antioxidants level in patients with epilepsy compared to healthy controls in the neurology clinic of two tertiary hospitals in Kaduna state, Northern Nigeria between June and December 2014. Seventy consenting patients with epilepsy made up of 35 persons who were ├ó┬?┬ą1 year on AEDs therapy and 35 newly diagnosed; against 35 age and sex matched healthy controls were recruited. The levels of antioxidants were determined by quantitative colorimetric method using assay kits. Statistical significance was determined using one-way analysis of variance (ANOVA) at a p-value of less than 0.05. One-hundred and five subjects were investigated. The mean age├?┬▒SEM of the patients on AEDs; newly diagnosed and controls were 33.91├?┬▒2.35, 31.25├?┬▒2.48 and 33.31├?┬▒1.80 years respectively. The levels of the three enzyme antioxidants (superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT)) were significantly decreased in the AEDs therapy group with GSH-Px and CAT of the AED therapy group being significantly more decreased than the newly diagnosed patients. This study also found significantly higher level of serum uric acid and malondialdehyde (MDA) in the patients on AEDs therapy. AEDs therapy significantly altered the level of antioxidants.

Biography :


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