Development of xanthines as adenosine A2A receptor selective antagonists: A systematic approach towards novel nondopaminergic therapy for Parkinsons disease

International Conference on Pharmaceutical Chemistry

September 05-07, 2016 Frankfurt, Germany

Ranju Bansal, Suman Rohilla, K N Klotz and Sonja Kachler

Panjab University, India

Scientific Tracks Abstracts: Med chem

Abstract :

Adenosine receptors represent a new promising target for the development of various drug candidates for the treatment of a wide range of biological disorders. Currently four AR subtypes A1, A2A, A2B and A3 have been recognized and pharmacologically characterized. Adenosine A2A receptor antagonism represents a novel non-dopaminergic approach in the treatment of Parkinson�s disease. Substituted xanthines represent the most potent class of adenosine receptor (AR) antagonists reported to date. Xanthine scaffold represents itself as a privileged motif, which offers numerous modifications at 1-, 3-, 7-, and 8-positions for the development of new potent and selective AR ligands. SAR studies have established that the structural modifications at 1- and 3-positions of the xanthine nucleus greatly affect the binding ability of the compounds for adenosine receptors. It has also been observed that the most remarkable alterations in potencies of the xanthines as antagonists of adenosine receptors result from appropriate substitution at the 8-position of this heterocyclic system. The current study describes a systematic approach to design and synthesize a new series of 1,3,7,8-tetrasubstituted xanthines as potent and selective adenosine A2A receptor ligands for the treatment of Parkinson�s Disease.

Biography :

Ranju Bansal is an active researcher and academician for last 25 years. Presently, she is a Professor at UIPS in Panjab University. She has published more than 80 research articles, has authored 1 book and has 6 patents to her credit. She has been awarded prestigious Commonwealth Academic Staff Fellowship for Postdoctoral studies at University of Strathclyde, UK. She is an active member of various professional bodies and has been designated as deputy coordinator of UGC -CAS programme of UIPS. Recently, she has published research in Chemical Reviews, a highest ranking journal in chemical sciences (Impact factor 45.6). She has been serving as an Editorial Board Member and reviewer of various journals of repute. Her areas of research interest include development of steroids and xanthines based new chemical entities of medicinal significance.

Email: ranju29in@yahoo.co.in