Circadian regulation of rejection after kidney transplantation

17^th International Conference on Nephrology & Urology

March 12-13, 2018 London, UK

Hajira Iftikhar

University of Manchester, England

Posters & Accepted Abstracts: J Nephrol Ther

Abstract :

Kidney transplants are of the few types of operations that can occur at any time over 24 hours. This retrospective observational study explores the impact of circadian rhythms in generating rejection. Data from 974 transplants that occurred in one hospital unit between 2004 and 2014 was collected and time of organ reperfusion and presence of rejection was recorded. From these records, 89 of those had inconclusive biopsy results and hospital records were investigated to find the diagnosis. 43 of these patients were those of whom notes were not found and these patients were assumed to not have rejection. Statistical analysis using JTK cycle and CircWave was used to determine involvement of circadian rhythms in rejection and found that there was weak circadian contribution. This weak association is not sufficient to conclude that circadian involvement is important enough to be considered in clinical practice. Therefore, more research is required regarding circadian involvement and transplantation to determine whether these results are reliable. By determining the peak times of rejection, these operating times can be avoided, or the patients could be primed to minimize rejection post-operatively. Reliance on patient records may not be the best way to determine circadian involvement due to the heavy dependency on record keeping of other healthcare professionals. hajira.iftikhar@student.manchester.ac.uk