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Breast hyperplasias, risk signature and Breast Cancer
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Cancer Science & Therapy

ISSN: 1948-5956

Open Access

Breast hyperplasias, risk signature and Breast Cancer


Joint Event on Cancer Treatment & Breast Cancer and Biomarkers

March 20-21, 2019 Paris, France

Indira Poola, Qingqi Yue, John Gillespie,Peggy Sullivan, Josephine Aguilar-Jakthong, Jianyu Rao,Abeer Shaaban, Edward Sauter, and Andrew Ricci

Silbiotech Inc., USA
University of California at Los Angeles, USA
Leeds Hospitals, UK
Hartford Hospital, UK
Queen Elizabeth Hospital Birmingham, UK
National Cancer Institute, UK

Keynote: J Cancer Sci Ther

Abstract :

Numerous clinical studies have established that diagnosis of hyperplastic masses increases the cancer risk by 2-5 fold. Clinical follow-up surveys have shown that ~20% and 10% of subjects diagnosed with atypical and non-atypical hyperpalsias respectively develop cancer subsequently and are the most suitable candidates for preventative therapies. However, there are no methods for identifying the above high risk subjects who will most likely develop future cancers and benefit from prophylactic measures. Due to lack of any risk stratification tools, healthcare providers as well as patients are faced with a dilemma in undertaking preventative measures. Our study purpose is to investigate a four marker risk signature, MMP-1, CEACAM6, HYAL1 and HEC1, using 440 hyperplastic tissues with up to 19 years of clinical follow-up information for risk stratification and identifying high risk subjects who will benefit from preventative therapies. We have assayed the marker levels in the hyperplasia tissues and combined their expression levels to obtain a composite value from 0-10 which we called a â??Cancer Risk Scoreâ??. We demonstrate that the four marker based risk scores predict subsequent cancer development with an accuracy of 91% and 86% for atypical and non-atypical subjects respectively. We have established a correlation between risk scores and cancer rates at 5 years, 10 years and beyond by stratifying the samples into Low (Score < 0.5), Intermediate (Score <= 5.4) and High (Score > 5.4) risk groups and Kaplan Meier survival analysis. Our results show that the cancer rates in the first five years among the low-, and intermediate risk groups were 2%, and 15% respectively among atypical as well as non-atypical subjects. In the high risk group, the cancer rates were 73% and 34% for atypical and non-atypical subjects respectively. The molecular risk stratification developed by us assesses a patientâ??s tumor biology based risk level in terms of a cancer risk score and categorizes the patient as low-, intermediate- or high risk for making informed treatment decisions (Figure 1). The outcomes of our study in conjunction with the already available prophylactic measures could prevent ~20%-25% of sporadic breast cancers (Grant Support: National Cancer Institute, National Institutes of Health (CA173919 and CA206774) and the National Science Foundation (IIP-1314287) awarded to I. Poola)..

Biography :

Indira Poola has completed her PhD in Biochemistry from Mysore University, Mysore, India and post-doctral training at the University of Michigan and Cornell University in the USA. She served as a Professor in Biochemistry and Molecular Biology and Surgery at Howard University Medical School, Washington, D.C. USA for 17 years. She is currently President of Silbiotech, Inc, in Gaithersburg, MD, USA. She has won 27 grant awards from 9 funding agencies totalling over $8Million. She has published more than 40 papers in highly reputed journals and has served as an adhoc reviewer for 24 journals. She has served as an adhoc grant reviewer for 10 different agencies including NIH, DoD, NSF, EPA, and Komen for the Cure.

E-mail: ipoola@silbiotech.com

 

Google Scholar citation report
Citations: 3968

Cancer Science & Therapy received 3968 citations as per Google Scholar report

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