M Shargorodsky, M Mashavi, H Oz and Z Matas
Wolfson Medical Center, Israel
Tel Aviv University, Israel
Posters & Accepted Abstracts: J Metabolic Synd
Objective: Not all obese individuals demonstrate similar metabolic profiles. The present study was designed to investigate an association between various obesity phenotypes and vascular atherosclerotic changes. Methods: The 246 study participants were divided into three groups according to presence of obesity and metabolic syndrome (MS): Group one included 91 non-obese subjects without MS; group two included 64 obese subjects without MS and; group three consisted 91 obese subjects with MS. Augmentation index (AI) was performed using SphygmoCor (version 7.1, AtCor Medical, Sydney, Australia). Results: AI differed significantly between groups; such that AI increased from group one to group three in a continuous fashion. The metabolically benign obese subjects had significantly higher AI than the metabolically benign non-obese one (p=0.016). Combination of obesity and MS was associated with further deterioration in terms of AI (p<0.0001). In univariate GLM analysis, significant by-group differences in AI persisted even after adjustment for age, sex and mean blood pressure. Conclusions: Metabolically benign obese individuals show an increased arterial stiffness compared to non-obese subjects, despite a comparable cardio metabolic risk profile. Obesity is associated with an adverse effect on blood vessels, independently of age, sex, blood pressure, parameters of glucose homeostasis and lipids.
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Journal of Metabolic Syndrome received 506 citations as per Google Scholar report