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Anticarcinogenic effect of coadministration of α-β unsaturated compounds and quercetin
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Cancer Science & Therapy

ISSN: 1948-5956

Open Access

Anticarcinogenic effect of coadministration of α-β unsaturated compounds and quercetin


10th Global Annual Oncologists Meeting

July 11-13, 2016 Cologne, Germany

Gabriela Carrasco Torres

CINVESTAV, Mexico

Posters & Accepted Abstracts: J Cancer Sci Ther

Abstract :

The effect of co-administration of ?±-?² unsaturated compounds derivatives of benzoic acid and the flavonoid Quercetin, were evaluated in a variety of established human cancer cell lines. The synergic effect of these two chemicals showed anti-proliferative activity in cancer liver cells of 90% and in cancer cervical cells of 60% at 48 h post-treatment. Additionally, significant events of apoptosis were observed in 90% of the cell population, when benzoic acid and quercetin were administered together. Independent treatments, quercetin or ?±-?² unsaturated compounds decrease the migratory ability of HepG2, HuH7 and HeLa, however the coadministration of both, exerted a higher effect. It is suggested by in silico studies of ?±- ?² unsaturated compounds, that through 1,4-addition reactions Michael type, they can selectively react with glutathione (GSH). High levels of GSH participate as a defence mechanism characteristic of cancer cells, thereby, inhibiting free radical induced cell death. Summarizing the co-administration of these compounds induce programmed cell death, probably by disrupting the cellular redox homeostasis, so further studies of the effect of independent or co-administration of these compounds, will give us the best way to use them as chemotherapeutic agents.

Biography :

Email: carrasco@cell.cinvestav.mx

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Citations: 3644

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