Analyzing marginal outcomes in pilot cancer clinical trials

Cancer Science & Therapy

ISSN: 1948-5956

Open Access

Analyzing marginal outcomes in pilot cancer clinical trials

3rd World Congress on Cancer Science & Therapy

October 21-23, 2013 DoubleTree by Hilton Hotel San Francisco Airport, CA, USA

Jimmy T. Efird

Accepted Abstracts: J Cancer Sci Ther

Abstract :

The analysis of small randomized cancer clinical trials poses known difficulty when the outcome measure is based on a marginal relative effects estimate. Confidence intervals for marginal relative effect estimates tend to be overly conservative and have little value in practice. In this presentation, we present a modified multinomial procedure for estimating marginal relative effect estimates and provide simulation results comparing the empirical and expected coverage of the estimated values.

Biography :

Jimmy T. Efird is an Associate Member of the Leo Jenkins Cancer at Brody School of Medicine. Additionally, he holds a joint appointment as Associate Professor in the Department of Public Health and as Epidemiologist/Chief Statistician in the Center for Health Disparities. He received his Ph.D. from Stanford University. His expertise includes statistical methods for assessing gene-environment interaction, clinical trial design, computing power and sample size for correlated samples, and multiplicity adjustments for confidence intervals. He has over 100 publications in scientific journals and technical proceedings. Additionally, he serves as a Senior Consultant for The NCRR-funded RCMI Translational Research Network Data and Technology Coordinating Center.


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