Accepted Abstracts: J Cancer Sci Ther
Bladder cancer is one of the most common cancers worldwide with transitional cell carcinoma (TCC) being the predominant form. Here, we report an integrated analysis of TCC by whole-genome, whole-exome, and transcriptome sequencing of 99 individuals with TCC. Beyond confirming recurrent mutations in genes previously identified as mutated in TCC, we identified additional altered genes and pathways that are implicated in TCC. Notably, we discovered frequent alterations in STAG2 and ESPL1 , two genes involved in the spindle checkpoint of the cell cycle. Furthermore, we also detected a recurrent fusion involving FGFR3 and TACC3 , another spindle checkpoint gene. To our knowledge, it is the first recurrent fusion that occurs in multiple types of solid tumors. Overall, 32 (32%) of the 99 tumors harbored genetic alterations in spindle checkpoint genes. Our analysis provides the first evidence that genetic alterations affecting the spindle checkpoint could be involved in bladder tumorigenesis and implicates a novel therapeutic possibility for bladder cancer.
Zhiming Cai, Ph.D. in Management and Medicine, is a Professor, and Ph.D. supervisor. He is the current president of Shenzhen Second People?s Hospital (The First Affiliated Hospital of Shenzhen University, the director of the Genitourinary Institution of Shenzhen University. In 1989, he started to persue his Ph.D. degree of Urinary Surgery in Sun Yat-Sen University, majored in genitourinary system oncology and male reproductive medicine. He is the principal investigator of 17 national fundings including "973", "863", National Nature Science Foundation of China (NSFC), published more than 160 articles, in which over 50 was included in Science Citation Index (SCI), including 3 papers published in Nature Genetics, Nature Biotechnology as the first author or corresponding author.