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Alkoxyamines for the in-situ generation of radicals as theranostic agents
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Cancer Science & Therapy

ISSN: 1948-5956

Open Access

Alkoxyamines for the in-situ generation of radicals as theranostic agents


5th World Congress on Cancer Therapy

September 28-30, 2015 Atlanta, USA

Paul Bremond

Aix-Marseille Universit?©, France

Scientific Tracks Abstracts: J Cancer Sci Ther

Abstract :

Alkoxyamines R1R2NOR3 are able to undergo homolysis upon chemical activation to release a stable nitroxide R1R2NOâ?¢, which can be used for DNP-MRI, and a transient alkyl radical R3â?¢, which can be used for killing tumor cells. By combining diagnostic and therapeutic activities into a single low-molecular weight molecule, alkoxyamines are new theranostic tools. We have developed this concept recently, and proved that they are reliable and controllable sources of in-situ generated radicals able to exhibit interesting biological and imaging properties.

Biography :

Paul Bremond has completed his PhD in chemistry in France, where he developed syntheses of several natural products. After being a postdoctoral associate at Harvard University, Cambridge, Ma, USA under the supervision of Prof. Yoshito Kishi, he was appointed Assistant Professor in Aix-Marseille Université. So far he has published more than 35 peer-reviewed papers in several fields of chemistry: organic, physical, radical and medicinal and one patent. He now focus on the synthesis of new alkoxyamines as theranostics agents.

Email: paul.bremond@univ-amu.fr

Google Scholar citation report
Citations: 3644

Cancer Science & Therapy received 3644 citations as per Google Scholar report

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