Technology Advancements in Sample Preparation

Journal of Bioanalysis & Biomedicine

ISSN: 1948-593X

Open Access

Opinion - (2022) Volume 14, Issue 3

Technology Advancements in Sample Preparation

Saransh Priyadarshan*
*Correspondence: Saransh Priyadarshan, Department of Biotechnology, Alagappa University, Karaikudi 630 003, Tamil Nadu, India, Email:
Department of Biotechnology, Alagappa University, Karaikudi 630 003, Tamil Nadu, India

Received: 02-Mar-2022, Manuscript No. JBABM-22-60715; Editor assigned: 04-Mar-2022, Pre QC No. P-60715; Reviewed: 17-Mar-2022, QC No. Q-60715; Revised: 22-Mar-2022, Manuscript No. R-60715; Published: 27-Mar-2022 , DOI: 10.37421/1948-593X.2022.14.316
Citation: Priyadarshan, Saransh. “Technology Advancements in Sample Preparation.” J Bioanal Biomed 14 (2022): 316.
Copyright: © 2022 Priyadarshan S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


In current history, there has been a growing interest in sample preparation for chromatography and capillary electrophoresis, including the development of new techniques and strategies, as well as theoretical description, in order to gain a better knowledge of the many processes. The early actions offered new technology to the community, while the latter efforts taught us how to use the technologies and turned sample preparation into a scientific discipline [1]. Improved selectivity and clean-up, improved analyte enrichment, reduced analysis time, reduced consumption of toxic organic solvents, and reduced sample volumes necessary for analysis were all important driving forces in this research [2].

Various contributors to the evolution of sample preparation have been invited to present their recent work in this special issue. Due to the restricted space in this volume and the fact that current research is such a diverse subject in terms of technology and applications, the current collection is meant to provide a flavour of the topic rather than a thorough review. Nonetheless, we believe that the papers will be of great importance and that they will inspire many more analytical chemists to continue to improve the subject of sample preparation in the future [3]. We will be able to process more samples in less time, eliminate interferences, detect compounds at lower concentration levels in complex matrices, and analyse new types of sample material as sample preparation advances; this will undoubtedly provide us with much more scientific knowledge of chemical and biological systems.



In the previous year, new sample preparation technologies were largely passive. Solid-phase extraction (SPE) sorbents and accessories, as well as a multiplatform integration of sample preparation and gas chromatography, were among the top performers (GC) [4]. There are three parts to this review. To begin, we'll go through sample preparation platforms and accessories that are specialised to GC. The following section introduces new solid-phase sorbents and sorbent-based products. Finally, we'll look at some sample preparation tools and technologies. Each section includes a tabular breakdown of the related items to help the reader understand some of the specifics behind these new products. The new products we discovered are displayed in the annotated table in all cases, with the text highlighting products that are particularly notable.

Gas chromatography

Markes International introduced Centri, a multiplatform sampling and concentration system for GC. To support a variety of sample techniques, including sorptive extraction, headspace sampling, solid-phase micro extraction (SPME), and thermal desorption, a combination of robotics and analyte trapping is used. For the extraction and characterisation of volatile and semi-volatile organic compounds, Centri's HiSorb sorbent extraction uses a large volume of polydimethylsiloxane adsorbent on a strong metal tip for robustness and increased sensitivity in either the headspace or immersion modes. A reminiscence trap is another element of the Centri. To avoid sample overload, high split flows might be used in the early GC separation of volatile samples [5].


For high sensitivity, the recollected material might be injected with smaller split ratios, as shown in Passive sampling, pumped sampling, dynamic headspace sampling, and direct desorption are all options for thermal desorption with the Centri. If there was a trend this year, it seemed to be toward bioanalysis, notably with SPE technology. The question is whether the trend in the coming years is targeted towards tool development or problem solving for food, environmental, and related studies.


  1. Pedersen-Bjergaard, Stig and Knut Einar Rasmussen. "New sample preparation technologies." Anal Bioana Chem 393 (2009): 779-779.
  2. Google Scholar, Crossref, Indexed at

  3. Raynie, Douglas. "New Sample Preparation Products and Accessories." LCGC North Americ 37 (2019): 298-302.
  4. Google Scholar, Crossref

  5. Pérez-Rodríguez, Michael, Roberto Gerardo Pellerano, Leonardo Pezza and Helena Redigolo Pezza. "An overview of the main foodstuff sample preparation technologies for tetracycline residue determination." Talanta 1 (2018): 1-21.
  6. Google Scholar, Crossref, Indexed at

  7. Raynie, Douglas. "Trends in sample preparation." (2016).
  8. Majors, Ronald E. "Application of existing sample preparation technologies to new areas." LC-GC North America 31, no. 11 (2013): 914-920.
  9. Google Scholar, Crossref

50+ Million Readerbase

Journal Highlights

Google Scholar citation report
Citations: 2511

Journal of Bioanalysis & Biomedicine received 2511 citations as per Google Scholar report

Journal of Bioanalysis & Biomedicine peer review process verified at publons

Indexed In

arrow_upward arrow_upward