Protective Effects of Picrorhiza Kurroa on Cyclophosphamide-Induced Immunological Disorder in Mice

Komlan Paul^*
*Correspondence: Komlan Paul, Department of University of Science and Technology of Togo, Faculty of Medical Sciences, West Africa, Togo, Email:

Commentary

On stepping into the twenty first century, we've got subjected ourselves to such an inclined surroundings that it's virtually become not possible for our natural system to convey America the fair proportion of protection from the antigens. Natural product resources offer the wonderful raw materials for the invention and development of novel immunomodulatory compounds. Immunomodulatory medicative plants are relatively a recent idea in pharmacognosy. In several of the pathological conditions, as mentioned on top of, the reaction is impaired. Hence, to keep up a disease-free state, modulation of the reaction, by either its stimulation or suppression, may be a useful medical care. Immunomodulators will offer validatory medical care to the therapy [1].

Immunosuppressants have already been utilized in transplantation surgery. The non-specific immune stimulation or immunopotentiation may be caused by the utilization of some medicative plants. Ayurvedic ideas of preventive health care have shown bound links with non-specific immunostimulation by such medicative plants. It’s currently become clear that natural merchandise represent distinguished and promising sources for attention-grabbing immunomodulating properties [2]. The innate system is that the 1st line of defense against associate substance insult and includes physical (skin), organic chemistry (complement, lysozyme, and interferon), and cellular parts (neutrophils, monocytes, macrophages). Once the innate reaction is insufficient to deal with infection, the adaptational response culminates within the production of antibodies, that are the effectors of body substance immunity, and therefore the activation of T lymphocytes, that are the effectors of cellmediated immunity [3]. Body substance immunity or B-cell immunity develops current antibodies, that are simple protein molecules that are capable of assaultive the offensive agent. Cell-mediated immunity is achieved by the formation of an oversized variety of activated lymphocytes that are specifically designed to destroy the foreign agents. Immunosuppression may be a common consequence of long-run cyclophosphamide (CP) medical care within the cancer patients. Reduction of immunological disorder effects could so become helpful to patients undergoing CP-chemotherapy. During this study, we, therefore, assessed the protecting effects of Picrorrhiza kurroa against cyclophosphamide-induced immunological disorder [4].

The rhizomes are bitter, acrid, cooling, laxative carminative organic process viscus, anthelmintic, medicine, depurative, cardio tonic, galactopurifier, and medication, anti-pyretic and anti-periodic, and purgative in massive doses. They’re conjointly helpful in gastropathy, flatulence, colic, cardiovascular disease, cough, asthma, bronchitis, hiccough, fever, diabetes, jaundice, hemorrhoids, and impurity of breast milk, and general frailness [5].

It is ended that the check extracts possessed promising immune stimulant properties. But, the alcoholic extract is less assailable than binary compound extract in manufacturing delayed-type hypersensitivity response.

References

1. Bin-Hafeez, Bilal, Iqbal Ahmad, Rizwanul Haque, and S. Raisuddin. "Protective effect of Cassia occidentalis L. on cyclophosphamide-induced suppression of humoral immunity in mice." J Ethnopharmacol 75 (2001): 13-18.

Google Scholar, Crossref, Indexed at

2. Puri, Anju, Ragini Saxena, R. P. Saxena, K. C. Saxena, Vandita Srivastava, and J. S. Tandon. "Immunostimulant agents from Andrographis paniculata." J Nat Prod 56 (1993): 995-999.

Google Scholar , Crossref, Indexed at

3. Jeena, K. Jose, K. L. Joy, and Ramadasan Kuttan. "Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on N-nitrosodiethylamine induced hepatocarcinogenesis." Cancer Lett 136 (1999): 11-16.

Google Scholar, Crossref, Indexed at

4. Makare, Neelam, Subhash Bodhankar, and Vinod Rangari. "Immunomodulatory activity of alcoholic extract of Mangifera indica L. in mice." J Ethnopharmacol 78 (2001): 133-137.

Google Scholar, Crossref, Indexed at

5. Chopra, Ram Nath. "Glossary of Indian medicinal plants." (1956).

Google Scholar, Indexed at