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Tuberculosis Of The Head And Neck | Open Access Journals
Journal of Inflammatory Bowel Diseases & Disorders

Journal of Inflammatory Bowel Diseases & Disorders

ISSN: 2476-1958

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Tuberculosis Of The Head And Neck

Tuberculosis of the central nervous system (CNS) is a very devastating form of tuberculosis which, even with appropriate anti-tuberculosis treatment, leads to unacceptable levels of morbidity and mortality. Despite the development of promising molecular diagnostic techniques, the diagnosis of CNS tuberculosis is largely based on insensitive microbiological methods and, as such, CNS tuberculosis remains a formidable diagnostic challenge. Information on the basic neuropathogenesis of Mycobacterium tuberculosis and the development of an appropriate animal model is desperately needed. The optimal regimen and duration of therapy are largely unknown, and with the increasing incidence of multidrug-resistant strains of M. tuberculosis, the development of well-tolerated and effective antibiotics remains a constant need. While the most widely used vaccine in the world largely targets this manifestation of tuberculosis, the BCG vaccine has not kept its promise of eliminating tuberculosis from the CNS. We propose this review to highlight the current understanding of the neuropathogenesis of M. tuberculosis, to discuss certain epidemiological, clinical, diagnostic and therapeutic aspects of CNS tuberculosis, and also to highlight the many unmet needs in this important area

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Citations: 77

Journal of Inflammatory Bowel Diseases & Disorders received 77 citations as per Google Scholar report

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