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Global Journal of Technology and Optimization

Global Journal of Technology and Optimization

ISSN: 2229-8711

Open Access
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Top Open Access Journals In Glucose Metabolism

Data about ordinary hepatic glucose digestion may assist with understanding pathogenic systems hidden weight and diabetes mellitus. Furthermore, liver glucose digestion is associated with glycosylation responses and associated with unsaturated fat digestion. The liver gets dietary sugars legitimately from the digestive tract by means of the entry vein. Glucokinase phosphorylates glucose to glucose 6-phosphate inside the hepatocyte, guaranteeing that a satisfactory progression of glucose enters the cell to be processed. Glucose 6-phosphate may continue to a few metabolic pathways. During the post-prandial period, most glucose 6-phosphate is utilized to combine glycogen by means of the arrangement of glucose 1-phosphate and UDP–glucose. Minor measures of UDP–glucose are utilized to frame UDP–glucuronate and UDP–galactose, which are contributors of monosaccharide units utilized in glycosylation. A second pathway of glucose 6-phosphate digestion is the arrangement of fructose 6-phosphate, which may either begin the hexosamine pathway to create UDP-N-acetylglucosamine or follow the glycolytic pathway to produce pyruvate and afterward acetyl-CoA. Acetyl-CoA may enter the tricarboxylic corrosive (TCA) cycle to be oxidized or might be traded to the cytosol to incorporate unsaturated fats, when abundance glucose is available inside the hepatocyte. At long last, glucose 6-phosphate may create NADPH and ribose 5-phosphate through the pentose phosphate pathway. Glucose digestion supplies intermediates for glycosylation, a post-translational alteration of proteins and lipids that tweaks their movement. Intrinsic lack of phosphoglucomutase (PGM)- 1 and PGM-3 is related with debilitated glycosylation. Notwithstanding process sugars, the liver produces glucose to be utilized by different tissues, from glycogen breakdown or from de novo synthesis utilizing essentially lactate and alanine (gluconeogenesis).

 

Keywords: diabetes, glucokinase, glucose, hexosamine pathway, pentose phosphate pathway

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Citations: 847

Global Journal of Technology and Optimization received 847 citations as per Google Scholar report

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