Thromboembolism | Open Access Journals

Journal of Anesthesiology and Pain Research

ISSN: 2684-5997

Open Access


Venous Thromboembolism (VTE) which broadly consists of deep vein thrombosis (DVT) and pulmonary embolism (PE) is associated with a poor prognosis in patients with cancer and remains a leading cause of mortality and morbidity. Cancer patients are at 6 to 7-fold increased risk of venous thromboembolism (VTE) compared with age-matched controls corresponding to an annual incidence of about one thrombotic event per 200 active cancer patients. Therefore, adequate management of VTE is of utmost importance for clinicians involved in the care of cancer patients. Patients were included if they were at least 18 years of age, had a diagnosis of cancer and concurrent radiological diagnosis of DVT and/or PE, and were prescribed treatment with either rivaroxaban or enoxaparin during the study period. Patients were excluded if the length of anticoagulation therapy was less than 30 days, if therapy with enoxaparin or rivaroxaban was initiated more than 6 months after DVT or PE diagnosis, or if they did not receive therapeutic doses of the therapy. Patients with DVT of upper extremity were also excluded. Venous thromboses are highly morbid. For patients that develop DVTs, the danger of recurrence is approximately 7% despite anticoagulation (AC) therapy. Beyond the acute complications and despite timely initiation of anticoagulation, DVTs can cause persistent chronic disease which will be severely disabling. PE also can have devastating chronic sequelae termed chronic thromboembolic pulmonary hypertension (CTEPH). Although the exact costs are difficult to quantify, it is thought that both clinic entities greatly increase the cost of venous thrombosis.  DVT classically presents with calf pain, thigh pain, or cramping. Suspected PE management is dependent on risk stratification. Wells’ or Geneva score are often wont to risk-stratify patients. The Geneva score assesses PE with parameters such as age, pulse, and haemoptysis.

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