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Terminal Elimination | Open Access Journals
Malaria Control & Elimination

Malaria Control & Elimination

ISSN: 2470-6965

Open Access

Terminal Elimination

The terminal plasma half-life is the time required to halve the plasma concentration after reaching pseudo-equilibrium, not the time required to eliminate half the administered dose. When the absorption process is not a limiting factor, the half-life is a hybrid parameter controlled by the plasma clearance and the extent of the distribution. On the other hand, when the absorption process is a limiting factor, the terminal half-life reflects the rate and extent of absorption and not the elimination process (pharmacokinetics of the scales). The terminal half-life is particularly relevant for multiple dosing regimens, as it controls the degree of drug accumulation, concentration fluctuations, and the time required to reach equilibrium.

 

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