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Malaria Control & Elimination

ISSN: 2470-6965

Open Access

Paul Chikezie


Owerri
Nigeria

Publications
  • Review Article
    Pathophysiology of Plasmodium falciparum-Infected Erythrocytes and Thiol- Mediated Antioxidant Detoxification Systems
    Author(s): Paul ChikeziePaul Chikezie

    Five species of intracellular protozoa of the genus Plasmodium cause malaria in human. The present review briefly highlighted the pathophysiology of Plasmodium falciparum infected erythrocyte and thiol-mediated antioxidant detoxification systems of P. falciparum that are required for survival of the malarial parasite in hyperoxidative intracellular environment. Scientific search engines such as PubMed, Pubget, Medline, EMBASE, Google Scholar, ScienceDirect and SpringerLink were used to retrieve online publications from 1976 to 2015. Haemoglobin that is taken up by the parasites into their acid food vacuole leads to the spontaneous oxidation of haem iron from Fe2+ to Fe3+, formation of superoxide radicals (O2•−), and subsequently, hydrogen peroxide (H2O2) and hydroxyl radicals (•− OH), which are highly reactive and cytotoxic oxygen intermediates. Additionally, t.. Read More»
    DOI: 10.4172/2470-6965.1000S1-003

    Abstract PDF

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