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Scholarly Open Access Journals In Pharmacogenomics | Open Access Journals
Pharmaceutical Regulatory Affairs: Open Access

Pharmaceutical Regulatory Affairs: Open Access

ISSN: 2167-7689

Open Access

Scholarly Open Access Journals In Pharmacogenomics

 Pharmacogenomics is the study of how genes affect a person's response to drugs. This relatively new field combines pharmacology (the science of drugs) and genomics (the study of genes and their functions) to develop effective and safe drugs and doses that will be adapted to a person's genetic makeup. Many drugs currently available are "one size fits all", but they don't work the same for everyone. It can be difficult to predict who will benefit from a drug, who will not respond at all, and who will experience negative side effects (called adverse drug reactions). Adverse drug reactions are a major cause of hospitalizations and deaths in the United States. Using the knowledge gained from the human genome project, researchers are learning how inherited differences in genes affect the body's response to drugs. These genetic differences will be used to predict whether a drug will work for a particular person and to help prevent adverse drug reactions. In pharmacogenomics, genomic information is used to study individual responses to drugs. When a gene variant is associated with a particular drug response in a patient, there is the potential for making clinical decisions based on genetics by adjusting the dosage or choosing a different drug, for example. Scientists assess gene variants affecting an individual's drug response the same way they assess gene variants associated with diseases: by identifying genetic loci associated with known drug responses, and then testing individuals whose response is unknown. Modern approaches include multigene analysis or whole-genome single nucleotide polymorphism (SNP) profiles, and these approaches are just coming into clinical use for drug discovery and development.

Conference Proceedings

Relevant Topics in Pharmaceutical Sciences

Google Scholar citation report
Citations: 533

Pharmaceutical Regulatory Affairs: Open Access received 533 citations as per Google Scholar report

Pharmaceutical Regulatory Affairs: Open Access peer review process verified at publons

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