Humoral alloimmunity mediated by anti-human leukocyte antigen (HLA) antibodies is a major challenge in renal transplantation and affects the longevity of the transplanted organ. The immunological risk of an individual patient is currently mainly assessed by the detection of HLA antibodies in serum, which are produced by plasma cells residing in long-lived bone marrow. However, humoral alloimmunity is complex, and alloreactive memory B cells are an additional factor in the interaction of immune cells. These recirculating “silent” cells are responsible for the immunological booster response by differentiating into antibody-producing cells upon a new encounter with the antigen. Historically, due to the lack of appropriate and routinely applicable analyzes to determine the presence and HLA specificity of alloreactive memory B cells, their contribution to the humoral alloimmune response has been clinically often suspected but could not be determined . In this review, we provide an overview of recent advances in alloreactive memory B cell detection techniques and discuss their strengths and limitations. In addition, we summarize experiences with these techniques in alloimmunized individuals and transplant recipients, thus highlighting unmet needs to be addressed in future studies.
Posters-Accepted Abstracts: Molecular and Genetic Medicine
Posters-Accepted Abstracts: Molecular and Genetic Medicine
Scientific Tracks Abstracts: Journal of Tissue Science and Engineering
Scientific Tracks Abstracts: Journal of Tissue Science and Engineering
Posters & Accepted Abstracts: Journal of Tissue Science and Engineering
Posters & Accepted Abstracts: Journal of Tissue Science and Engineering
Scientific Tracks Abstracts: Metabolomics:Open Access
Scientific Tracks Abstracts: Metabolomics:Open Access
Keynote Forum Day 1: Metabolomics:Open Access
Keynote Forum Day 1: Metabolomics:Open Access
Journal of Genetics and DNA Research received 3 citations as per Google Scholar report
Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi 