Immunogenetics is the branch of medical genetics that makes the relationship between the immune system and genetics. Autoimmune diseases, such as type 1 diabetes, are complex genetic traits that result from defects in the immune system. Immunogenetics is the study of the genetic basis for the immune response. It includes the study of normal immunological pathways and the identification of genetic variations that cause immune defects, which can lead to the identification of new therapeutic targets for immune diseases.
Organ transplantation is an effective way to treat end-stage organ disease. Extending graft survival is one of the major goals of the modern era of organ transplantation. However, the long-term survival of the graft has not improved significantly in recent years despite the improvement in patient management and the advancement of the immunosuppression regimen. Antibody-induced rejection is a major obstacle to long-term graft survival. Antibodies specific for human donor leukocyte antigen (HLA) were initially identified as a major cause of antibody-induced rejection. Recently, with the development of solid phase test reagents, the contribution of non-HLA antibodies in organ transplantation is beginning to be appreciated. Here, we review the role of most of the non-HLA antibodies studied, including the angiotensin II type 1 receptor (AT1R), K-α-tubulin and vimentin antibodies, in the transplantation of solid organ, and let's discuss the possible mechanism by which these antibodies are stimulated.
Editorial: Journal of Genetics and DNA Research
Editorial: Journal of Genetics and DNA Research
Commentry: Journal of Genetics and DNA Research
Commentry: Journal of Genetics and DNA Research
Scientific Tracks Abstracts: Molecular and Genetic Medicine
Scientific Tracks Abstracts: Molecular and Genetic Medicine
Posters & Accepted Abstracts: Molecular and Genetic Medicine
Posters & Accepted Abstracts: Molecular and Genetic Medicine
Posters-Accepted Abstracts: Molecular and Genetic Medicine
Posters-Accepted Abstracts: Molecular and Genetic Medicine
Scientific Tracks Abstracts: Metabolomics:Open Access
Scientific Tracks Abstracts: Metabolomics:Open Access
Journal of Genetics and DNA Research received 3 citations as per Google Scholar report
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