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Journal of Nephrology & Therapeutics

Journal of Nephrology & Therapeutics

ISSN: 2161-0959

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Renal Fibrosis

Fibrous disorders are common, take many forms and can be life threatening. There is no better example of this than the progressive fibrosis that accompanies all chronic kidney disease. Kidney fibrosis is a direct result of the kidney's limited ability to regenerate after an injury. Kidney scarring causes progressive loss of kidney function, ultimately leading to end-stage renal failure and the need for kidney dialysis or transplantation. Although it manifests histologically as an increase in the extracellular matrix, we know that Histological appearance may be de novo synthesis of the matrix (mainly collagen) or disproportionate loss of renal parenchyma. In both cases, the process depends on a resident mesenchymal cell, called myofibroblast, and is independent of the etiology of the disease. We can potentially improve fibrosis, either indirectly by modifying the environment of renal functions, or more directly by interfering with the activation and function of myofibroblasts. However, although kidney fibrosis shares many common features with the wound healing response in other organs, we also recognize that the consequences can be very specific to the kidneys. This review highlights the similarities and differences between this process in the kidney and other organs, and considers the therapeutic implications.

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Citations: 784

Journal of Nephrology & Therapeutics received 784 citations as per Google Scholar report

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