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Journal of Molecular Histology & Medical Physiology

Journal of Molecular Histology & Medical Physiology

ISSN: 2684-494X

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Non-alcoholic fatty liver disease (NAFLD) is a major health problem and the most frequently diagnosed chronic liver disease among 25% of the world's population. Obesity, insulin resistance, accumulation of toxic lipid free radicals, generation of oxidative stress, overconsumption of fats containing diet meals and lack of exercise are the main factors responsible for the development of NAFLD . During NAFLD, increased oxidative stress and the production of a huge number of toxic free radicals activate a number of pro-inflammatory and inflammatory pathways. The signaling mechanisms of TGF-β play a central role in the maintenance of normal liver homeostasis. TGF-β1, one of the three isoforms in the TGF-β family, has an important role at different stages of chronic liver disease. TGF-β1 promotes the activation of HSC and the production of the extracellular matrix (ECM), which further contributes to the progression of NAFLD. In this review, we describe the role of TGF-β1 in different phases of progressive NAFLD as well as the signaling mechanism.

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Citations: 33

Journal of Molecular Histology & Medical Physiology received 33 citations as per Google Scholar report

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