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Physical Exercise Peer-review Journals | Open Access Journals
Journal of Physiotherapy & Physical Rehabilitation

Journal of Physiotherapy & Physical Rehabilitation

ISSN: 2573-0312

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Physical Exercise Peer-review Journals

Physical exercise is an important stimulus for the regulation of multiple metabolic and transcriptional processes in skeletal muscle. For example, exercise increases the absorption of glucose in skeletal muscles, and after exercise there is an increase in the rates of glucose absorption and glycogen synthesis. A single exercise session can also induce transient changes in skeletal muscle gene transcription and can alter protein metabolism rates, both of which can be chronic adaptations to repeated periods of exercise. The main challenge in exercise biology is to reduce the basic molecular signaling mechanisms that control these important metabolic and transcriptional events in skeletal muscle. In this review, we summarize research from recent years that has shown that physical exercise can regulate multiple cascades of intracellular signaling in skeletal muscle. It is now well established that physical exercise or muscle contractile activity can activate three of the signaling pathways of mitogen-activated protein kinases, including kinases 1 and 2 regulated by the extracellular signal, kinase c-Jun NH2. -terminal and p38. Exercise can also robustly increase the activity of AMP-activated protein kinase, as well as several additional molecules, including glycogen synthase kinase 3, Akt, and kinase p70 S6. A fundamental objective of signaling research is to determine the biological consequences of exercise-induced signaling through these molecules, and this review also provides an update on progress in this area.

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Citations: 378

Journal of Physiotherapy & Physical Rehabilitation received 378 citations as per Google Scholar report

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