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Journal of Bioanalysis & Biomedicine

Journal of Bioanalysis & Biomedicine

ISSN: 1948-593X

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Osteoporotic Spine Review Journal

Human parathyroid hormone (hPTH) (1–34) was approved in 2004 for the treatment of severe osteoporosis. Osteoporosis Canada Clinical Guidelines Committee Members Carried Out a Systematic Review of Randomized Controlled Trials (RCTs) to Evaluate the Efficacy and Safety of HPAP for Preventing Fractures in Women and Men menopausal men with osteoporosis.
We searched MEDLINE, EMBASE, HTA, Current Contents and the Cochrane Controlled Trials Registry for data published from 1966 to February 2005. A systematic literature search for RCTs was performed using the Cochrane Collaborative approach . We identified 12 trials that randomly assigned patients to hPTH or placebo or hPTH or an active comparator and lasted at least 1 year. Results included changes in bone mineral density (BMD), fractures, back pain and adverse events. Two independent reviewers summarized the data on the characteristics and results of the study.
 HPTH (1–34) significantly increases BMD in the lumbar spine, with smaller increases in the femoral neck and total hip. HPTH (1–84) significantly increases BMD in the lumbar spine. The data show a significant reduction in vertebral and non-vertebral fractures with hPTH (1–34) in postmenopausal women who have already experienced vertebral fractures. There were no fracture data comparing the approved dose of hPTH (1–34) with active comparators.
There is level I evidence that hPTH (1–34) significantly increases BMD at all skeletal sites except the radius and significantly reduces the risk of new vertebral and non-vertebral fractures in postmenopausal women who have had anterior fractures.

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Journal of Bioanalysis & Biomedicine received 3099 citations as per Google Scholar report

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