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Pharmacoeconomics: Open Access

Pharmacoeconomics: Open Access

ISSN: 2472-1042

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Open Access Articles On Pharmacophore

The Pharmacophore is that the group of those properties that form an important a part of a drug. A Pharmacophore could also be defined because the essential geometric arrangement of atoms or functional groups necessary to supply a given biological response. The strict IUPAC definition of a pharmacophore is: A pharmacophore is that the ensemble of steric and electronic features that's necessary to make sure the optimal supramolecular interactions. Pharmacophore mapping is one among the main elements of drug design within the absence of structural data of the target receptor. The tool initially applied to discovery of lead molecules now extends to steer optimization. Pharmacophores are often used as queries for retrieving potential leads from structural databases (lead discovery), for designing molecules with specific desired attributes (lead optimization), and for assessing similarity and diversity of molecules using pharmacophore fingerprints. It also can be wont to align molecules supported the 3D arrangement of chemical features or to develop predictive 3D QSAR models. This review begins with a quick historical overview of the pharmacophore evolution followed by coverage of the developments in methodologies for pharmacophore identification over the amount from inception of the pharmacophore concept to recent developments of the more sophisticated tools like Catalyst, GASP, and DISCO.

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Citations: 106

Pharmacoeconomics: Open Access received 106 citations as per Google Scholar report

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