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Non-viral Vectors | Open Access Journals
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Journal of Genetics and DNA Research

ISSN: 2684-6039

Open Access
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Non-viral Vectors

Gene-based therapy is the intentional modulation of gene expression in specific cells to treat pathological conditions. This modulation is accomplished by introducing exogenous nucleic acids such as DNA, mRNA, small interfering RNA (siRNA), microRNA (miRNA), or antisense oligonucleotides. Given the large size and negative charge of these macromolecules, their delivery is usually mediated by carriers or vectors. In this review, we present the biological barriers to gene delivery in vivo and discuss recent advances in materials science, nanotechnology, and nucleic acid chemistry that have yielded promising non-viral delivery systems, some of which they are being tested in clinical trials. The diversity of these systems highlights the recent progress of gene-based therapy using non-viral approaches.

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