Induced Pluoripotent Stem Cells

The derivation of pluripotent embryonic stem (ES) cell lines has opened up new areas of research in basic and applied science, most significantly in developmental biology and regenerative medicine. While application-oriented research has for the most part focussed on obtaining differentiated, organotypic cells from ES cells for future cell grafting therapies, ES cells have more immediate potential for use in toxicological in vitro assays used during drug development. ES cells are derived from blastocyst-stage embryos and offer an in vitro model for early development, thus enabling tests for teratogenicity testing in a human cell culture system and avoiding the pitfalls of inter-species differences. Differentiated, organotypic cells obtained from ES cells can potentially replace the primary cells and cell lines currently used for in vitro toxicology by offering a more consistent and potentially limitless source of differentiated cells. This can facilitate the establishment of comprehensive toxic genomics and -proteomics databases and complement current databases that rely on data obtained from animal experiments. More recently, induced pluripotent stem (iPS) cells with ES cell-like properties have been obtained through reprogramming of somatic cells, thus enabling the generation of disease-specific cell lines.

High Impact List of Articles

Conference Proceedings

Cytogenetic investigations in bone marrow cancers and cancer predisposing chromosomal instability syndromes
Binay Kumar Raut
Scientific Tracks Abstracts: Molecular and Genetic Medicine
Cytogenetic investigations in bone marrow cancers and cancer predisposing chromosomal instability syndromes
Binay Kumar Raut
Scientific Tracks Abstracts: Molecular and Genetic Medicine
Human parvovirus B19 infections have emerged but given a back seat: A Pioneer work from India indicates high disease burden
Janak Kishore
Scientific Tracks Abstracts: Molecular and Genetic Medicine
Human parvovirus B19 infections have emerged but given a back seat: A Pioneer work from India indicates high disease burden
Janak Kishore
Scientific Tracks Abstracts: Molecular and Genetic Medicine
Electrospinning & 3D printing in tissue engineering: Challenges and recent advances
Dimitrios Lamprou
Scientific Tracks Abstracts: Journal of Tissue Science and Engineering
Electrospinning & 3D printing in tissue engineering: Challenges and recent advances
Dimitrios Lamprou
Scientific Tracks Abstracts: Journal of Tissue Science and Engineering
Cell-based therapy in patients with acute myocardial infarction and impaired left ventricular function could reduce major adverse cardiac events
M M Micheu, N Oprescu, L Calmac, A Scarlatescu, D Pitic and M Dorobantu
Posters-Accepted Abstracts: Journal of Tissue Science and Engineering
Cell-based therapy in patients with acute myocardial infarction and impaired left ventricular function could reduce major adverse cardiac events
M M Micheu, N Oprescu, L Calmac, A Scarlatescu, D Pitic and M Dorobantu
Posters-Accepted Abstracts: Journal of Tissue Science and Engineering
A computed biochemical conversion network revealed a broad spectrum of hydroxycinnamic acid ester conjugates of glucaric acid in Isatis tinctoria leaves
Kieu Oanh T Nguyen, Eric Gontier and Rebecca Dauwe
Scientific Tracks Abstracts: Metabolomics:Open Access
A computed biochemical conversion network revealed a broad spectrum of hydroxycinnamic acid ester conjugates of glucaric acid in Isatis tinctoria leaves
Kieu Oanh T Nguyen, Eric Gontier and Rebecca Dauwe
Scientific Tracks Abstracts: Metabolomics:Open Access

Human Genetics & Embryology