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Hypersensitivity With TB | Open Access Journals
Journal of Hypertension: Open Access

Journal of Hypertension: Open Access

ISSN: 2167-1095

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Hypersensitivity With TB

Type IV hypersensitivity usually occurs at least 48 hours after exposure to an antigen. These are activated T cells, which release cytokines and chemokines, as well as macrophages and cytotoxic CD8 + T cells which are attracted to these fragments. Delayed type hypersensitivity and granuloma play a major role in tissue damage seen in infections with slow growing intracellular organisms such as M. tuberculosis (tuberculosis), M. leprae (leprosy) and H. capsulatum. Many clinical manifestations of Chlamydia disease, particularly trachoma, appear to result from delayed type hypersensitivity triggered by Chlamydia heat shock proteins. It is not an autoimmune phenomenon directed against heat shock proteins in general, as the unique rather than preserved portions of these proteins appear to be involved.

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