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Heart Regeneration Review Articles | Open Access Journals
Journal of Lasers, Optics & Photonics

Journal of Lasers, Optics & Photonics

ISSN: 2469-410X

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Heart Regeneration Review Articles

The heart is a pump made up of cardiac myocytes  and other types of cells, the proper functioning of which is essential to quality of life. The ability to trigger regeneration of the heart muscle after injury eludes adult mammals, a deficiency of great clinical impact. Significant research efforts are trying to change this situation thanks to advances in cell therapy  or the activation of endogenous regeneration mechanisms that only exist early in life. Unlike mammals, lower vertebrates such as zebrafish demonstrate an impressive natural capacity for heart regeneration throughout life. This review will cover recent advances in the field of cardiachttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342383/ regeneration with a focus on endogenous regenerative capacity and its potential manipulation.

As more and more nations have developed, heart failure has become one of the leading causes of death worldwide. This condition, in which the heart is unable to provide sufficient blood flow to other vital organs, is most often triggered by an ischemic event such as myocardial infarction (MI) or non-ischemic events causing also myocardial loss. After the death of the cardiomyocytes, there is no significant replacement of the old muscle with a new one, and a scar rich in collagen is generated by fibroblasts concomitant with the elimination of cellular debris. Although scarring is essential as a quick fix, a non-contractile scar cannot restore cardiac output and can cause arrhythmia. In many cases, signs of heart failure can be managed medically, while other cases require a heart transplant. Without a doubt, regenerative strategies that improve heart function by restoring cardiomyocytes electrically coupled to injured or sick hearts would be the windfall for cardiologists and their patients. In this review, we will focus on the efforts that have been made to discover, understand and improve the capacity for regeneration after the loss of cardiomyocytes.

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