White graphene quantum dots surface coated with MnO2 nanosheet for dual imaging guided photothermal therapy

8^th International Conference and Exhibition on Lasers, Optics & Photonics

November 15-17, 2017 | Las Vegas, USA

Joon Hwang, Vishnu Revuri, Yong-Kyu Lee, Md Nafiujjaman, Kang Moo Huh, Dong Yun Lee and In-Kyu Park

Korea National University of Transportation, South Korea
Chungnam National University, Republic of Korea
Hanyang University, Republic of Korea

Posters & Accepted Abstracts: J Laser Opt Photonics

Abstract :

Recently white-light emitting materials have gained significant attention for diverse applications, optoelectronic, biological and others. In this study, we synthesized white-light-emitting graphene quantum dots (WGQDs) from organic sources and investigated dual imaging guided photo therapeutic effects. We have characterized our WGQD with a diameter around 20 nm by FESEM and TEM and found 3-5 graphene layers by AFM. Our results demonstrate that the developed WGQDs display enhanced intracellular and cellular uptake with multi-channel intracellular fluorescence in all three primitive channels (blue, green and red). Moreover, the developed WGQDs displayed multi-channel imaging in vivo along with enhanced tumor homing properties. After that, WGQDs were surface coated with manganese oxide (WGQD-MnO2) and then investigated MRI effects and photo thermal effects. Our studies showed that WGQD-MnO2 nanoparticles showed positive contrast effects due to manganese oxide. WGQD-MnO2 nanoparticles increased 25�°C upon irradiation of laser at 2 W/cm2 for in vitro and in vivo respectively. In another hand, WGQDs increased 25�°C upon irradiation of laser. WGQD-MnO2 nanoparticles exhibited enhanced photothermal effects on cancer in vitro and in vivo, respectively than WGQDs only. Finally, these nanoparticles could enhance tumor therapeutic efficacy guided with proper diagnostics.

Biography :

Yong-Kyu Lee has completed his PhD from Gwangju Institute of Science and Technology and Post-doctoral studies from Georgia Institute of Technology Department of Biomedical Engineering (USA). He is the Professor/Director of Chemical & Biological Engineering and 4D Biomaterial Research Center. He has published more than 100 papers in reputed journals and 30 registered patents (corresponding author).