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Heart Regeneration Open Access Articles | Open Access Journals
Journal of Hypertension: Open Access

Journal of Hypertension: Open Access

ISSN: 2167-1095

Open Access
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Heart Regeneration Open Access Articles

In adult vertebrates, the zebrafish has a rather exceptional ability to effectively regenerate its heart after an injury. This bony fish has thus become a leading genetic model organism to elucidate the natural mechanisms of successful cardiac restoration. Given its potential biomedical importance, parallel analyzes between zebrafish and mammals aim to identify the permissive and restrictive factors modulating the underlying proliferation of cardiomyocytes. The recent discovery that certain other species of bony fish have a lower regenerative skill than that of the zebrafish opens up new opportunities for comparative studies within the framework of animal physiology and similar organ structure. Here, we review the recently identified modulators of cardiomyocyte proliferation in zebrafish and highlight the results obtained by this comparative approach.

The heart is one of the most important vertebrate organs due to its vital blood pumping function. Therefore, a quick and effective mechanism to heal heart injuries would be particularly beneficial. Restoring the myocardium to a state prior to the injury obviously represents the optimal strategy. However, cardiac regeneration is absent in adult mammals and has only been observed in a few anamniotic vertebrates, such as zebrafish and axolotls. As the heart does not have competent cardiac stem cells, the regeneration mechanism relies solely on the proliferation capacity of pre-existing cardiomyocytes (CM) [2, 3, 4, 5]. Understanding how the cellular plasticity of CM is modulated is therefore  of major scientific and therapeutic relevance

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Citations: 614

Journal of Hypertension: Open Access received 614 citations as per Google Scholar report

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